Science

T h e   S c i e n c e   B e h i n d   A x o n M D

Neurotrophic Support: NGF & BDNF Pathways

Healthy cognition depends on two essential proteins:

  • NGF (Nerve Growth Factor) maintains, protects, and repairs neurons
  • BDNF (Brain-Derived Neurotrophic Factor), enhances learning, memory, and synaptic plasticity

AxonMD includes ingredients like Lion’s Mane mushroom (Hericium erinaceus) containing hericenones and erinacines, bioactive compounds shown to stimulate NGF.
This supports:

  • Neuronal growth and regeneration
  • Myelin maintenance
  • Stronger and more flexible neural networks
  • Improved cognitive speed and memory consolidation

Myelin Integrity & Neural Communication

Myelin is the fatty insulation wrapped around axons, enabling rapid electrical signaling.
Stronger myelin = faster processing, clearer thinking, sharper focus.

AxonMD uses DHA, omega-3s, and mushroom-derived compounds to support healthy myelin formation and repair. These nutrients integrate directly into neuronal membranes, improving membrane fluidity and allowing neurons to fire more efficiently.

This results in:

  • Faster signal transmission
  • Reduced cognitive fatigue
  • Better multitasking and processing speed
  • Enhanced overall mental performance

Mitochondrial Energy Production (ATP)

Your brain consumes 20–25% of your body's total energy, despite being only 2% of your mass.
Every thought, memory, and action relies on ATP.

AxonMD includes mitochondrial-supporting nutrients that help:

  • Increase ATP production
  • Protect mitochondria from oxidative stress
  • Improve neuronal stamina
  • Support long-term cellular energy

More mitochondrial efficiency = clearer focus, stronger endurance, and improved brain resiliency.

Y o u r   B r a i n .

Inflammation Modulation

The brain is selective, not everything crosses the blood–brain barrier
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S c i e n c e   I s   O u r   S t a n d a r d

Doctor-Developed & Research-Led Formulation

Every AxonMD formula is created with clinical insight from experts in neurobiology, molecular biology, and functional health. We study pathways, not trends — focusing on:

  • Neurotrophic signaling (NGF, BDNF)
  • Synaptic plasticity mechanisms
  • Mitochondrial ATP production
  • HPA-axis regulation & stress chemistry
  • Neuroinflammatory pathways (microglial modulation)
  • Membrane lipid composition & DHA integration

Our formulations are built backward from these pathways, ensuring each ingredient choice is mechanistically meaningful and supported by peer-reviewed research.

Evidence-Based Ingredient Selection

A nutrient is only useful if your brain can absorb it.

We prioritize ingredient forms that are:

  • Highly bioavailable
  • Lipid-compatible (ideal for neural tissue)
  • Able to cross the blood–brain barrier
  • Protected from oxidation and degradation

For example:

  • We use algae-derived DHA because it integrates directly into neuronal membranes.
  • We use mushroom extracts with quantified beta-glucans and erinacines for consistent NGF stimulation.
  • We select bioactive adaptogens shown to influence cortisol and stress-response pathways.

Synergistic Formulation (Not Single-Ingredient Thinking)

The brain is a network, so our formulas are too.

AxonMD designs multi-pathway synergy, meaning ingredients are chosen for how they work together, not alone. For example:

  • DHA strengthens membrane fluidity → helping neurons respond better to NGF stimulation from Lion’s Mane.
  • Adaptogens regulate cortisol → enhancing neurotransmitter stability and mental clarity.
  • Omega-3s reduce neuroinflammation → amplifying the effects of antioxidants and mitochondrial support nutrients.

Each mechanism supports another.
The result is a more complete cognitive effect.